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RX 300 comes as one trim level. Buyers have a choice of front-wheel drive ($33,005) or four-wheel drive ($34,605).

Four-wheel antilock disc brakes (ABS) are standard. Front and side airbags are standard along with shoulder belts with pretensioners and force limiters. The lack of a three-point shoulder belt in the rear seat center position is a disappointing omission for a vehicle costing more than $33,000, however.